Indeed. And I wonder I those in the profession really understand just how badly trust has been eroded. And how difficult it is going to be to earn it back.
Well, the positive thing is that the white lab coats are themselves often aware or deeply frustrated too. Sometimes the doctors joke about certain studies being faked; often times they know that the therapy being given has no expectation of helping but it may be psychologically desired by a patient to have something happening, so a benevolent doctor will give something that won't do any harm. Like any area in life, choose your physician based on personality so that they can help you with critical wisdom and sheltering the patient.
While I believe most doctors intend to be benevolent beings, and help their patients, I'm having a hard time as a retired Registered Nurse/Midwife thinking of a medication/treatment that does not have the potential for side effects/harms.
I've come to the conclusion that Allopathic Medicine apart from trauma medicine is generally not of benefit to humanity
I agree with you. 'Won't do any harm' / 'may not do any good' is the apparent norm-perception of several things that are offered on a regular basis as supportive therapies (easy example, anti-oxidant infusion). However when one considers cell biology, it's not reasonable to say that these things are without some effect. A wise practitioner will be sensitive to these unknowns and complexities; someone who is arrogant and not well-read will be dismissive of the patient and of the nuances of their own work.
Indeed. "Four out of five doctors [the only ones surveyed] say that ..." 😉
Carl Sagan argued that some 90% of us are scientifically illiterate - though his evidence for that may have been a bit thin on the ground. But largely true I think, and probably why so many are such easy marks for the frauds and grifters among the scientific community.
I feel if I'm looking at something in writing and can process it I can do an ok job at sense making. But in real life...if a guy or gal is confident, has conviction in what they are saying. I'm toast.
"If you can fake sincerity then you have it made" ... 😉
Reminds me of a closing paragraph from "Fear and Loathing in Las Vegas: A Savage Journey to the Heart of the American Dream" - indeed:
"I took another big hit off the amyl, and by the time I got to the bar my heart was full of joy. I felt like a monster reincarnation of Horatio Alger ... a Man on the Move, and just sick enough to be totally confident."
Takes some effort to develop a skeptical frame of mind, although that too has its limitations.
When I was 17, I listened to a speaker at a tradeshow describe his work for the National Cancer Institute. Working late nights, diligently, he discovered that the entire premise of cancer as an overgrowth of unwanted cells was incorrect. He was ecstatic. His life's work paid off. He couldn't wait to share his evidence. The starting point of all research was incorrect so solutions never came. When he examined different starting points (like synthetic chemical overwhelm, genetic damage passed down through generations, epigenetic triggers, metabolic suffocation from synthetic foodstuffs, etc.) he found solutions galore.
By morning, he had no job and was threatened with legal action--and more corporal threats to his life and family. Done.
Nicholas Gonzalez, willian Kelley, Mike mew, and many people and treatments that get suppressed by being bought out or lengthy legal hassles that inhibit the potential for a better world. Like hydroxycloroquine and ivermectin. Useful Natural compounds have to be modified so as to be patentable which allows funnel into money marketschemes. I wonder lawyers involved in the haxsines live with their work covering up or perhaps each is a link in the chain such that none understands complicity in murders.
Would be interested in hearing any thoughts you might have on Bret Weinstein's claim that animal studies (specifically in lab mice) have been tainted by evolutionary pressures in artificial environments breeding mice resistant to drug damage.
I'd really like to hear some additional experts weigh in on the topic. It seems absolutely central to several egregious failures in pharmaceuticals over the last decade but.... radio silence.
Good stuff here! I highly recommend reading "The Immortal Life of Henrietta Lacks" by Rebecca Skloot. It's a fascinating look at the woman behind the HeLa cells as well as the moral dilemmas of human experimentation - I'd say Henrietta got her revenge. I would also recommend looking into the murine telomeres which Bret Weinstein discusses in the Darkhorse podcast #131. I'll be sure to add "A Conspiracy of Cells" to my reading list.
Was thinking a similar thing about poor Henrietta (loved that book!), would she have been proud that her cells were used to help the human race? Not after reading this. Thanks for making me smarter, and hopefully wiser El Gato Malo.
Our society is obsessed with "truth" and yet--especially in experts--the truth is about as welcome as a bucket of horse manure. I can see why young radicals are more inclined to burn it all down, but in this case I think the hard and necessary work is to systematically demand that these scientists "be" what they've been pretending to be.
Who even knows what we might accomplish for humankind if we stopped allowing biased scientists (and their corporate owners) to "pretend" they've already accomplished things, and instead insisted that they really learn, invent, correct and accomplish innovations.
When previous work is the springboard for subsequent efforts -- and what research doesn't rely on presuppositions or the 'proven' results of previous work -- there is always the danger that what is taken for granted is mistaken in some fundamental way and is therefore for nought. And it is a sad fact that when erroneous assumptions are laid bare, the dissemination of this awareness tends to meet fierce resistance from the cognoscenti. Paradigm shifts take time.
Reading this excellent piece, I was reminded of work by Paul Marmet in an other discipline:
There is no excuse for not knowing the source of HEp-2 cells.
ATTCC is the cell bank which maintains cell culture stocks and distributes them for research. And they say clearly in their info on HEp-2 cells that…
“This line was originally thought to be derived from an epidermoid carcinoma of the larynx but was subsequently found – based on isoenzyme analysis, HeLa marker chromosomes, and DNA fingerprinting – to have been established via HeLa cell contamination.…”
It's might look like an accumulated technical debt in a huge programming product. Red bars on the figures and involving more and more related mistakes gives us idea, that the total amount of problems grows exponentially. Which means that the whole project "Biology as Science" currently are very close to the stage, when the cost of every improvement will be greater than total amount of possible benefits.
For informational systems we use a term "refactoring", and even in our field, project owners do everything possible to delay those painful changes, especially when it doesn't bring any delivery in production.
For the Biology, we are actually don't have a term "Product Owner". Hypothetically it "All the people over the globe", but it means nothing in terms of funding. Anyway, Science as a self-regulated system obviously shows signs of aging.
You know the more I read the less I'm able to project safety and trust onto whoever happens to be wearing a white lab coat.
Indeed. And I wonder I those in the profession really understand just how badly trust has been eroded. And how difficult it is going to be to earn it back.
Well, the positive thing is that the white lab coats are themselves often aware or deeply frustrated too. Sometimes the doctors joke about certain studies being faked; often times they know that the therapy being given has no expectation of helping but it may be psychologically desired by a patient to have something happening, so a benevolent doctor will give something that won't do any harm. Like any area in life, choose your physician based on personality so that they can help you with critical wisdom and sheltering the patient.
While I believe most doctors intend to be benevolent beings, and help their patients, I'm having a hard time as a retired Registered Nurse/Midwife thinking of a medication/treatment that does not have the potential for side effects/harms.
I've come to the conclusion that Allopathic Medicine apart from trauma medicine is generally not of benefit to humanity
I agree with you. 'Won't do any harm' / 'may not do any good' is the apparent norm-perception of several things that are offered on a regular basis as supportive therapies (easy example, anti-oxidant infusion). However when one considers cell biology, it's not reasonable to say that these things are without some effect. A wise practitioner will be sensitive to these unknowns and complexities; someone who is arrogant and not well-read will be dismissive of the patient and of the nuances of their own work.
Indeed. "Four out of five doctors [the only ones surveyed] say that ..." 😉
Carl Sagan argued that some 90% of us are scientifically illiterate - though his evidence for that may have been a bit thin on the ground. But largely true I think, and probably why so many are such easy marks for the frauds and grifters among the scientific community.
I feel if I'm looking at something in writing and can process it I can do an ok job at sense making. But in real life...if a guy or gal is confident, has conviction in what they are saying. I'm toast.
"If you can fake sincerity then you have it made" ... 😉
Reminds me of a closing paragraph from "Fear and Loathing in Las Vegas: A Savage Journey to the Heart of the American Dream" - indeed:
"I took another big hit off the amyl, and by the time I got to the bar my heart was full of joy. I felt like a monster reincarnation of Horatio Alger ... a Man on the Move, and just sick enough to be totally confident."
Takes some effort to develop a skeptical frame of mind, although that too has its limitations.
I've never seen that movie or read that book. I may fix that soon
👍🙂 Though I can't say that I've ever seen the movie - generally find the books to be better bangs for the buck than the movies made from them.
Fascinating! (It looks like the purpose of cancer research is to mop up the funding dollars from governments and charities - not to find cures.)
When I was 17, I listened to a speaker at a tradeshow describe his work for the National Cancer Institute. Working late nights, diligently, he discovered that the entire premise of cancer as an overgrowth of unwanted cells was incorrect. He was ecstatic. His life's work paid off. He couldn't wait to share his evidence. The starting point of all research was incorrect so solutions never came. When he examined different starting points (like synthetic chemical overwhelm, genetic damage passed down through generations, epigenetic triggers, metabolic suffocation from synthetic foodstuffs, etc.) he found solutions galore.
By morning, he had no job and was threatened with legal action--and more corporal threats to his life and family. Done.
I heard him when I was 17. I'm 57.
Nicholas Gonzalez, willian Kelley, Mike mew, and many people and treatments that get suppressed by being bought out or lengthy legal hassles that inhibit the potential for a better world. Like hydroxycloroquine and ivermectin. Useful Natural compounds have to be modified so as to be patentable which allows funnel into money marketschemes. I wonder lawyers involved in the haxsines live with their work covering up or perhaps each is a link in the chain such that none understands complicity in murders.
Would be interested in hearing any thoughts you might have on Bret Weinstein's claim that animal studies (specifically in lab mice) have been tainted by evolutionary pressures in artificial environments breeding mice resistant to drug damage.
Amazing we both raised this simultaneously!
I'd really like to hear some additional experts weigh in on the topic. It seems absolutely central to several egregious failures in pharmaceuticals over the last decade but.... radio silence.
Good stuff here! I highly recommend reading "The Immortal Life of Henrietta Lacks" by Rebecca Skloot. It's a fascinating look at the woman behind the HeLa cells as well as the moral dilemmas of human experimentation - I'd say Henrietta got her revenge. I would also recommend looking into the murine telomeres which Bret Weinstein discusses in the Darkhorse podcast #131. I'll be sure to add "A Conspiracy of Cells" to my reading list.
Was thinking a similar thing about poor Henrietta (loved that book!), would she have been proud that her cells were used to help the human race? Not after reading this. Thanks for making me smarter, and hopefully wiser El Gato Malo.
Thank you for shining light on this issue!
"mistakes that quietly get passed on to thousands or tens of thousands of papers."
The Science Virus!
https://roundingtheearth.substack.com/p/the-science-virus-part-i-orwellian
Mathew, you run a great substack. Please keep up the exceptional work. I came here via Heather Heying, and am delighted to see you in the comments.
I haven’t read this anywhere else. I unpaused my subscription.
The scope of pollution of science literature discussed reminds me of Bret Weinstein’s claims about mice used in so much biological research.
https://pubmed.ncbi.nlm.nih.gov/11909679/
Our society is obsessed with "truth" and yet--especially in experts--the truth is about as welcome as a bucket of horse manure. I can see why young radicals are more inclined to burn it all down, but in this case I think the hard and necessary work is to systematically demand that these scientists "be" what they've been pretending to be.
Who even knows what we might accomplish for humankind if we stopped allowing biased scientists (and their corporate owners) to "pretend" they've already accomplished things, and instead insisted that they really learn, invent, correct and accomplish innovations.
Combine this lack of solid foundation
with the push to get rid of regulations:
https://2ndsmartestguyintheworld.substack.com/p/rna-for-modernas-omicron-booster
When previous work is the springboard for subsequent efforts -- and what research doesn't rely on presuppositions or the 'proven' results of previous work -- there is always the danger that what is taken for granted is mistaken in some fundamental way and is therefore for nought. And it is a sad fact that when erroneous assumptions are laid bare, the dissemination of this awareness tends to meet fierce resistance from the cognoscenti. Paradigm shifts take time.
Reading this excellent piece, I was reminded of work by Paul Marmet in an other discipline:
https://www.newtonphysics.on.ca/einstein/appendix2.html
The reality is indeed that 'the science' -- in direct proportion to the complexity of the issues at hand -- is never settled.
NO EXCUSE!
There is no excuse for not knowing the source of HEp-2 cells.
ATTCC is the cell bank which maintains cell culture stocks and distributes them for research. And they say clearly in their info on HEp-2 cells that…
“This line was originally thought to be derived from an epidermoid carcinoma of the larynx but was subsequently found – based on isoenzyme analysis, HeLa marker chromosomes, and DNA fingerprinting – to have been established via HeLa cell contamination.…”
https://www.atcc.org/products/ccl-23
It's might look like an accumulated technical debt in a huge programming product. Red bars on the figures and involving more and more related mistakes gives us idea, that the total amount of problems grows exponentially. Which means that the whole project "Biology as Science" currently are very close to the stage, when the cost of every improvement will be greater than total amount of possible benefits.
For informational systems we use a term "refactoring", and even in our field, project owners do everything possible to delay those painful changes, especially when it doesn't bring any delivery in production.
For the Biology, we are actually don't have a term "Product Owner". Hypothetically it "All the people over the globe", but it means nothing in terms of funding. Anyway, Science as a self-regulated system obviously shows signs of aging.
This post helps sum up this entire space.
I believe I heard Dr. Mikovits discuss this a while back. Trust nothing in the way of literature results is the lesson.
I believe I heard Dr. Mikovits discuss this a while back. Trust nothing in the way of literature results is the lesson.